I have had 0 malware and virus issues after I installed Comodo Internet Security Free. Highly powerfull firewall and antivirus in same package. Also comes with a host intrusion prevention system that monitors every single change to your files, registry, folders, Internet settings, everything. If you so desire. Love iiiit.
But MSE, yeah sure why not. Plus Malwarebytes anti malware.
Other you could also try is Superantispyware. Great stuff and free.